Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Min Jung Lee¹  Jaechan Leem¹  Yu Mi Kang¹  Jung Eun Jang¹  Woo Je Lee¹  Chang Hee Jung¹  Joong-Yeol Park²  Yoo La Lee³  Hae Kyeong Yoon³  So Mi Seol³ 

[1] Asan Diabetes Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Asan Diabetes Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Poongnap-dong, Songpa-gu, 138-736, Seoul, Republic of Korea;Asan Institute of Life Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea;

关键词: Angiopoietin-like protein 2;    Atherosclerosis;    Carotid;    Intima media thickness;    Type 2 diabetes;   

DOI  :  10.1186/s12933-015-0198-z

 received in 2015-01-20, accepted in 2015-03-21,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAlthough recent animal studies have suggested that angiopoietin-like protein 2 (ANGPTL2), a novel inflammatory adipokine, is likely to be involved in the pathogenesis of atherosclerosis, in rodents, little is known regarding whether serum ANGPTL2 level is also associated with atherosclerosis in humans, especially in patients with type 2 diabetes. The aim of this study was to investigate whether serum ANGPTL2 concentration is associated with atherosclerosis by measuring carotid intima-media thickness (IMT) in subjects with type 2 diabetes without previous history of cardiovascular diseases. In addition, we examined the clinical and biochemical variables associated with serum ANGPLT2 concentration.MethodsWe measured the circulating ANGPTL2 level in 166 subjects (92 men and 74 women; mean age of 60.0 years) with type 2 diabetes. Measurements of carotid IMT were performed in all subjects.ResultsSerum ANGPTL2 concentration was positively correlated with carotid IMT (r = 0.220, p = 0.004). In multiple linear regression, serum ANGPTL2 concentration was independently associated with increased carotid IMT along with older age, male gender, and higher systolic blood pressure. Higher levels of hemoglobin A1c and high-sensitivity C-reactive protein were significantly associated with elevated serum ANGPTL2 concentration in subjects with type 2 diabetes.ConclusionsSerum ANGPTL2 concentration was significantly and positively associated with carotid atherosclerosis in patients with type 2 diabetes, suggesting that ANGPTL2 may be important in the atherosclerosis in humans.

【 授权许可】

Unknown   
© Jung et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.