Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes

Cardiovascular Diabetology

Joong-Yeol Park¹  Hae Kyeong Yoon³  So Mi Seol³  Yoo La Lee³  Jaechan Leem²  Jung Eun Jang²  Yu Mi Kang²  Min Jung Lee²  Woo Je Lee²  Chang Hee Jung² 

[1] Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Poongnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea;Asan Diabetes Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Asan Institute of Life Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea

关键词: Type 2 diabetes;    Intima media thickness;    Carotid;    Atherosclerosis;    Angiopoietin-like protein 2;   

Others  :  1177365
DOI  :  10.1186/s12933-015-0198-z

 received in 2015-01-20, accepted in 2015-03-21,  发布年份 2015

【 摘 要 】

Background

Although recent animal studies have suggested that angiopoietin-like protein 2 (ANGPTL2), a novel inflammatory adipokine, is likely to be involved in the pathogenesis of atherosclerosis, in rodents, little is known regarding whether serum ANGPTL2 level is also associated with atherosclerosis in humans, especially in patients with type 2 diabetes. The aim of this study was to investigate whether serum ANGPTL2 concentration is associated with atherosclerosis by measuring carotid intima-media thickness (IMT) in subjects with type 2 diabetes without previous history of cardiovascular diseases. In addition, we examined the clinical and biochemical variables associated with serum ANGPLT2 concentration.

Methods

We measured the circulating ANGPTL2 level in 166 subjects (92 men and 74 women; mean age of 60.0 years) with type 2 diabetes. Measurements of carotid IMT were performed in all subjects.

Results

Serum ANGPTL2 concentration was positively correlated with carotid IMT (r = 0.220, p = 0.004). In multiple linear regression, serum ANGPTL2 concentration was independently associated with increased carotid IMT along with older age, male gender, and higher systolic blood pressure. Higher levels of hemoglobin A1c and high-sensitivity C-reactive protein were significantly associated with elevated serum ANGPTL2 concentration in subjects with type 2 diabetes.

Conclusions

Serum ANGPTL2 concentration was significantly and positively associated with carotid atherosclerosis in patients with type 2 diabetes, suggesting that ANGPTL2 may be important in the atherosclerosis in humans.

【 授权许可】

   
2015 Jung et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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