Engineering cell factories for producing building block chemicals for bio-polymer synthesis

Microbial Cell Factories

Review

Hideo Kawaguchi¹  Akihiko Kondo²  Yota Tsuge³  Kengo Sasaki³ 

[1] Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan;Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan;Biomass Engineering Program, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Kanagawa, Japan;Organization of Advanced Science and Technology, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan;

关键词: Metabolic engineering;    Bio-polymers;    Lactic acid;    Succinic acid;    Adipic acid;    Putrescine;    Cadaverine;    High-performance polymers;    Corynebacterium glutamicum;    Escherichia coli;   

DOI  :  10.1186/s12934-016-0411-0

 received in 2015-09-13, accepted in 2016-01-05,  发布年份 2016

来源: Springer

【 摘 要 】

Synthetic polymers are widely used in daily life. Due to increasing environmental concerns related to global warming and the depletion of oil reserves, the development of microbial-based fermentation processes for the production of polymer building block chemicals from renewable resources is desirable to replace current petroleum-based methods. To this end, strains that efficiently produce the target chemicals at high yields and productivity are needed. Recent advances in metabolic engineering have enabled the biosynthesis of polymer compounds at high yield and productivities by governing the carbon flux towards the target chemicals. Using these methods, microbial strains have been engineered to produce monomer chemicals for replacing traditional petroleum-derived aliphatic polymers. These developments also raise the possibility of microbial production of aromatic chemicals for synthesizing high-performance polymers with desirable properties, such as ultraviolet absorbance, high thermal resistance, and mechanical strength. In the present review, we summarize recent progress in metabolic engineering approaches to optimize microbial strains for producing building blocks to synthesize aliphatic and high-performance aromatic polymers.

【 授权许可】

CC BY   
© Tsuge et al. 2016