Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study

BMC Medical Genetics

Research Article

Elena Zholdybaeva¹  Aisha Iskakova¹  Nurgul Sikhayeva²  Erlan Ramanculov³  Nuria Saigi-Morgui⁴  Chin-Bin Eap⁵ 

[1] National Center for Biotechnology, 13/5 Korgalzhyn str, 010000, Astana, Kazakhstan;National Center for Biotechnology, 13/5 Korgalzhyn str, 010000, Astana, Kazakhstan;L.N. Gumilyov Eurasian National University, Astana, Kazakhstan;School of Science and Technology, Nazarbayev University, Astana, Kazakhstan;National Center for Biotechnology, 13/5 Korgalzhyn str, 010000, Astana, Kazakhstan;L.N. Gumilyov Eurasian National University, Astana, Kazakhstan;Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, 1008, Prilly-Lausanne, Switzerland;Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, 1008, Prilly-Lausanne, Switzerland;School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland;

关键词: Genetic variants;    Kazakh cohort;    Metabolic syndrome;    Obesity;    Type 2 diabetes mellitus;   

DOI  :  10.1186/s12881-017-0443-2

 received in 2017-04-10, accepted in 2017-07-13,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort.MethodsA total of 1336 subjects, including 408 T2DM patients and 928 control subjects, were recruited from an outpatient clinic and genotyped for 32 polymorphisms previously associated with T2DM and obesity-related phenotypes in other ethnic groups. For association studies, the chi-squared test or Fisher’s exact test for binomial variables were used. Logistic regression was conducted to explore associations between the studied SNPs and the risk of developing T2DM, obesity, and MS, after adjustments for age and sex.ResultsAfter excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). In addition, examination of general unmatched T2DM and control cohorts revealed significant associations between T2DM and SNPsrs1799883 (FABP2) and rs9939609 (FTO). Furthermore, polymorphisms in the FTO gene were associated with increased obesity risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with the risk of developing MS in general unmatched cohorts.ConclusionWe confirmed associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant associations with anthropometric and metabolic traits. In particular, FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to MS and obesity in this cohort.

【 授权许可】

CC BY   
© The Author(s). 2017