Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

BMC Medical Genetics

Research Article

Christine M. Albert¹  Hans-Henrik Tilsted²  Christian Juhl Terkelsen³  Lisette Okkels Jensen⁴  Mikkel Hougaard⁴  Stefan Sattler⁵  Javad Jabbari⁵  Jacob Tfelt-Hansen⁵  Bo Gregers Winkel⁵  Charlotte Glinge⁵  Bjarke Risgaard⁵  Reza Jabbari⁵  Thomas Engstrøm⁶  Stig Haunsø⁷ 

[1] Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA;Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark;Department of Cardiology, Aarhus University Hospital, Skejby, Nørrebrogade, 44, 8000, Aarhus C, Denmark;Department of Cardiology, Odense University Hospital, Søndre Blvd. 29, 5000, Odense C, Denmark;Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark;Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark;Department of Cardiology, University of Lund, Lund, Sweden;Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark;Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Juliane Mariesvej 20, 2100, Copenhagen Ø, Denmark;

关键词: Ventricular fibrillation;    Atrial fibrillation;    Myocardial infarction;    ST-elevation myocardial infarction;    Sudden cardiac death;    Genetics;    Single nucleotide polymorphisms;   

DOI  :  10.1186/s12881-017-0497-1

 received in 2017-03-01, accepted in 2017-11-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI).MethodsWe investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case–control study among first STEMI-patients of Danish ancestry.ResultsWe included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model.ConclusionIn this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

【 授权许可】

CC BY   
© The Author(s). 2017