Associations between toenail arsenic concentration and dietary factors in a New Hampshire population

Nutrition Journal

Research

Pamela J Bagley¹  Kathryn L Cottingham²  Tracy Punshon²  Joann F Gruber³  J Steven Morris⁴  Diane Gilbert-Diamond⁵  Margaret R Karagas⁵  M Scot Zens⁵  Vicki Sayarath⁵ 

[1] Biomedical Libraries, Dartmouth College, 03755, Hanover, NH, USA;Department of Biological Sciences, Dartmouth College, 03755, Hanover, NH, USA;Department of Biological Sciences, Dartmouth College, 03755, Hanover, NH, USA;Section of Biostatistics and Epidemiology, Dartmouth Medical School, 03755, Hanover, NH, USA;Research Reactor Center, University of Missouri and Harry S Truman Memorial Veterans Hospital, 65211, Columbia, MO, USA;Section of Biostatistics and Epidemiology, Dartmouth Medical School, 03755, Hanover, NH, USA;

关键词: Arsenic;    Epidemiology;    Biomarkers;    Lipids;    Fatty acids;    Fish;    One-carbon metabolism;    Folate;   

DOI  :  10.1186/1475-2891-11-45

 received in 2011-09-02, accepted in 2012-06-29,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown.MethodsAs part of a population-based case–control study of skin and bladder cancer from the USA, we evaluated relationships between consumption of dietary factors and arsenic concentrations in toenail clippings. Consumption of each dietary factor was determined from a validated food frequency questionnaire. We used general linear models to examine the associations between toenail arsenic and each dietary factor, taking into account potentially confounding effects.ResultsAs expected, we found an inverse association between ln-transformed toenail arsenic and consumption of vitamin B12 (excluding supplements) and animal protein. Unexpectedly, there were also inverse associations with numerous dietary lipids (e.g., total fat, total animal fat, total vegetable fat, total monounsaturated fat, total polyunsaturated fat, and total saturated fat). Finally, increased toenail arsenic concentrations were associated with increased consumption of long chain n-3 fatty acids.ConclusionIn a relatively well-nourished population exposed to relatively low levels of arsenic via water, consumption of certain dietary lipids may decrease toenail arsenic concentration, while long chain n-3 fatty acids may increase toenail arsenic concentration, possibly due to their association with arsenolipids in fish tissue.

【 授权许可】

Unknown   
© Gruber et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.