Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

BMC Cancer

Research Article

Julie Gentil¹  Marie-Laure Poillot¹  Tienhan Sandrine Dabakuyo¹  Patrick Arveux¹  Pegdwende Olivia Dialla¹  Patrick Roignot²  Ariane Darut-Jouve³  Sophie Marilier⁴  Valérie Quipourt⁴ 

[1] Breast and Gynaecologic Cancer Registry of Cote d’Or, Centre Georges François Leclerc, BP 77980, 1 rue Professeur Marion, 21079, Dijon Cedex, France;EA 4184, Faculty of Medicine, University of Burgundy, 7 boulevard Jeanne d’Arc, 21000, Dijon, France;Centre de Pathologie, 33 rue Nicolas Bornier, 21000, Dijon, France;Clinique Clément-Drevon, 9 rue Princes de Condé, 21000, Dijon, France;Unité Pilote de Coordination en Oncogériatrie en Côte-d’Or, Hôpital de jour Gériatrique, Hôpital de Champmaillot, 2 rue Jules Violle, 21079, Dijon Cedex, France;

关键词: Breast cancer;    Elderly women;    Predictors of treatment;    Prognostic factors;    Relative survival;   

DOI  :  10.1186/1471-2407-12-472

 received in 2012-08-01, accepted in 2012-10-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundA large proportion of women with breast cancer (BC) are elderly. However, there is a lack of information regarding BC prognostic factors and care in this population. The aims of this study were to assess the prognostic factors of relative survival (RS) among women with BC aged ≥ 75 years old and to identify the predictive factors of treatments administered to this population.MethodsA population-based study was performed using data from the Cote d’Or breast and gynaecological cancer registry. Women aged 75 years and older with primary invasive BC and resident in Cote d’Or at the time of diagnosis made between January 1998 and December 2008 were retrospectively selected. Prognostic factors of RS were estimated in a generalized linear model with a Poisson error structure. RS rate for the whole population was given at 5 years. Logistic regression models were used to identify the predictors of the treatments administered.ResultsSix hundred and eighty-one women were included. Median age at diagnosis was 80. Comorbidities (p=0.02), pT stage (p=0.04), metastases (p=<0.001), having a family doctor (p=0.03) and hormone-receptor status (p=0.006) were independent prognostic factors of RS. The RS rate at 5 years for the whole population was 78.2%, 95%CI = [72.2-83.0]. Age, pT stage, metastases, histoprognostic SBR grade, hormone receptor status and comorbidities were frequently found to be predictors of treatment with surgery alone, hormone therapy alone, breast conserving surgery plus adjuvant therapy and mastectomy plus adjuvant therapy.ConclusionsComorbid conditions adversely affect survival in older women with breast cancer. Moreover the results of this study showed that there are numerous predictors of the type of treatment administered, and that the most important were age and comorbidities.

【 授权许可】

Unknown   
© Dialla et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.