Determinants of Glasgow outcome scale in patients with severe traumatic brain injury for better quality of life

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Dharmajaya, R.^1 ; Sari, D.K.^2 ; Ganie, R.A.^3

Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik General Hospital, Medan, Indonesia^1

Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^2

Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^3

关键词: Brain injury;    Brain-derived neurotrophic factors;    Cohort studies;    Glasgow Outcome Scale;    Intra-cranial pressure;    Prognostic factors;    Quality of life;    Traumatic Brain Injuries;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012206/pdf
DOI  :  10.1088/1755-1315/125/1/012206

来源: IOP

【 摘 要 】

Primary and secondary brain injury may occur with severe traumatic brain injury. Secondary traumatic brain injury results in a more severe effect compared to primary traumatic brain injury. Therefore, prevention of secondary traumatic brain injury is necessary to obtain maximum therapeutic results and accurate determination of prognosis and better quality of life. This study aimed to determine accurate and noninvasive prognostic factors in patients with severe traumatic brain injury. It was a cohort study on 16 subjects. Intracranial pressure was monitored within the first 24 hours after traumatic brain injury. Examination of Brain-Derived Neurotrophic Factor (BDNF) and S100B protein were conducted four times. The severity of outcome was evaluated using Glasgow Outcome Scale (GOS) three months after traumatic brain injury. Intracranial pressure measurement performed 24 hours after traumatic brain injury, low S100B protein (6.16pg/ml) 48 hours after injury indicate good prognosis and were shown to be significant predictors (p