The effects of multifunctional MiR-122-loaded graphene-gold composites on drug-resistant liver cancer

Journal of Nanobiotechnology

Research

Yaqin Zhang¹  Bin Liu²  Gen Zhang³  Heming Wu⁴  Yi Yuan⁴  Ming Li⁴  Yanjun Kang⁵  Nongyue He⁶  Xin Zeng⁷ 

[1] Department of Biochemistry and Molecular Biology, Nanjing Medical University, 210029, Nanjing, China;Department of Biomedical Engineering, Nanjing Medical University, 210029, Nanjing, China;Department of Cell Biology, Nanjing Medical University, 210029, Nanjing, China;The State Key Laboratory of Bioelectronics, Department of Biological Science and Medical Engineering, Southeast University, 210096, Nanjing, China;Institute of Stomatology, Nanjing Medical University, 210029, Nanjing, China;Jiangnan University Medical School, 214122, Wuxi, Jiangsu, China;The State Key Laboratory of Bioelectronics, Department of Biological Science and Medical Engineering, Southeast University, 210096, Nanjing, China;The State Key Laboratory of Bioelectronics, Department of Biological Science and Medical Engineering, Southeast University, 210096, Nanjing, China;Maternal and Child Health Institute, Nanjing Maternity and Child Health Care Hospital, 210029, Nanjing, China;

关键词: Graphene;    Gold nanoparticles;    Cell apoptosis;    Control release;    Target;   

DOI  :  10.1186/s12951-015-0070-z

 received in 2014-11-03, accepted in 2015-01-23,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNano drugs have attracted increased attention due to their unique mode of action that offers tumor-inhibiting effects. Therefore, we have previously explored functionalized and drug-loaded graphene-gold nanocomposites that induced cancer cell apoptosis.ResultsIn the present study, we developed a combination of monoclonal P-glycoprotein (P-gp) antibodies, folic acid (FA) and miR-122-loaded gold nanoparticles on graphene nanocomposites (GGMPN), which promoted drug-resistant HepG2 cell apoptosis with drug targeting and controlled release properties. We also investigated related apoptosis proteins and apoptosis signal pathways by GGMPN treatment in vitro and in vivo. Moreover, we further demonstrated the inhibition of tumor growth and the apoptosis-inducing effect by means of GGMPN with a semiconductor laser in a xenograft tumor model.ConclusionIn conclusion, our results collectively suggested that GGMPN could serve as a novel therapeutic approach to control tumor cell apoptosis and growth.

【 授权许可】

Unknown   
© Yuan et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.