Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy

Journal of Cardiovascular Magnetic Resonance

Research

Shahriar Iravanian¹  Gregory R Hartlage¹  Michael S Lloyd¹  R Patrick Magrath III²  Jonathan D Suever²  John N Oshinski³ 

[1] Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology / Emory University, 1364 Clifton Road, Suite AG30, 30322, Atlanta, GA, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology / Emory University, 1364 Clifton Road, Suite AG30, 30322, Atlanta, GA, USA;Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA;

关键词: Electrophysiology;    Cardiac resynchronization therapy;    Cardiovascular magnetic resonance;    Electromechanical delay;   

DOI  :  10.1186/1532-429X-16-4

 received in 2013-10-28, accepted in 2013-12-27,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIt is important to understand the relationship between electrical and mechanical ventricular activation in CRT patients. By measuring local electrical activation at multiple locations within the coronary veins and myocardial contraction at the same locations in the left ventricle, we determined the relationship between electrical and mechanical activation at potential left ventricular pacing locations.MethodsIn this study, mechanical contraction times were computed using high temporal resolution cine cardiovascular magnetic resonance (CMR) data, while electrical activation times were derived from intra-procedural local electrograms.ResultsIn our cohort, there was a strong correlation between electrical and mechanical delay times within each patient (R2 = 0.78 ± 0.23). Additionally, the latest electrically activated location corresponded with the latest mechanically contracting location in 91% of patients.ConclusionsThis study provides initial evidence that our method of obtaining non-invasive mechanical activation patterns accurately reflects the underlying electromechanical substrate of intraventricular dyssynchrony.

【 授权许可】

Unknown   
© Suever et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.