Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy

Journal of Cardiovascular Magnetic Resonance

John N Oshinski²  Michael S Lloyd¹  Shahriar Iravanian¹  R Patrick Magrath III³  Gregory R Hartlage¹  Jonathan D Suever³ 

[1] Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology / Emory University, 1364 Clifton Road, Suite AG30, Atlanta, GA 30322, USA

关键词: Electromechanical delay;    Cardiovascular magnetic resonance;    Cardiac resynchronization therapy;    Electrophysiology;   

Others  :  801972
DOI  :  10.1186/1532-429X-16-4

 received in 2013-10-28, accepted in 2013-12-27,  发布年份 2014

【 摘 要 】

Background

It is important to understand the relationship between electrical and mechanical ventricular activation in CRT patients. By measuring local electrical activation at multiple locations within the coronary veins and myocardial contraction at the same locations in the left ventricle, we determined the relationship between electrical and mechanical activation at potential left ventricular pacing locations.

Methods

In this study, mechanical contraction times were computed using high temporal resolution cine cardiovascular magnetic resonance (CMR) data, while electrical activation times were derived from intra-procedural local electrograms.

Results

In our cohort, there was a strong correlation between electrical and mechanical delay times within each patient (R² = 0.78 ± 0.23). Additionally, the latest electrically activated location corresponded with the latest mechanically contracting location in 91% of patients.

Conclusions

This study provides initial evidence that our method of obtaining non-invasive mechanical activation patterns accurately reflects the underlying electromechanical substrate of intraventricular dyssynchrony.

【 授权许可】

   
2014 Suever et al.; licensee BioMed Central Ltd.

【 图 表 】

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