Effects of butter from mountain-pasture grazing cows on risk markers of the metabolic syndrome compared with conventional Danish butter: a randomized controlled study

Lipids in Health and Disease

Research

Tue Drachmann¹  Lars I. Hellgren¹  Søren K. Jensen²  Louise B. Werner³  Tine Tholstrup³  Rikke A. Petersen³  Marianne Raff³ 

[1] Center for Biological Sequence Analysis, DTU Systems Biology, Technical University of Denmark, 2800, Lyngby, Denmark;Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, Aarhus University, 8830, Tjele, Denmark;Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, 1958, Frederiksberg, Denmark;

关键词: Dairy-fat;    Low-input system;    Phytanic acid;    LDL cholesterol;    Oral glucose tolerance test;   

DOI  :  10.1186/1476-511X-12-99

 received in 2013-03-01, accepted in 2013-06-28,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThere is considerable interest in dairy products from low-input systems, such as mountain-pasture grazing cows, because these products are believed to be healthier than products from high-input conventional systems. This may be due to a higher content of bioactive components, such as phytanic acid, a PPAR-agonist derived from chlorophyll. However, the effects of such products on human health have been poorly investigated.ObjectiveTo compare the effect of milk-fat from mountain-pasture grazing cows (G) and conventionally fed cows (C) on risk markers of the metabolic syndrome.DesignIn a double-blind, randomized, 12-week, parallel intervention study, 38 healthy subjects replaced part of their habitual dietary fat intake with 39 g fat from test butter made from milk from mountain-pasture grazing cows or from cows fed conventional winter fodder. Glucose-tolerance and circulating risk markers were analysed before and after the intervention.ResultsNo differences in blood lipids, lipoproteins, hsCRP, insulin, glucose or glucose-tolerance were observed. Interestingly, strong correlations between phytanic acid at baseline and total (P<0.0001) and LDL cholesterol (P=0.0001) were observed.ConclusionsLack of effects on blood lipids and inflammation indicates that dairy products from mountain-pasture grazing cows are not healthier than products from high-input conventional systems. Considering the strong correlation between LDL cholesterol and phytanic acid at baseline, it may be suggested that phytanic acid increases total and LDL cholesterol.Trial registrationClinicalTrials.gov, NCT01343589

【 授权许可】

CC BY   
© Werner et al.; licensee BioMed Central Ltd. 2013