Extracts of okra (Abelmoschus esculentus L.) improves dyslipidemia by amelioratinglipid profile while not affectinghs-CRP levelsin streptozotocin-induced rats

Sustainable Agriculture Transformation for The Nations Welfare of Indonesia and Malaysia

Nabila, M.^1 ; Damayanthi, E.^2 ; Marliyati, S.A.^2

Master Student in Human Nutrition, Graduate School of Bogor, Agricultural University, Bogor, Indonesia^1

Lecturer at Nutritional Science Study Program, Department of Community Nutrition, Bogor Agricultural University, Bogor, Indonesia^2

关键词: Abelmoschus esculentus;    Control groups;    LDL cholesterol;    Lipid lowering;    Methanolic extracts;    Sprague-Dawley rats;    Total cholesterols;    Type-2 diabetes;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/196/1/012039/pdf
DOI  :  10.1088/1755-1315/196/1/012039

来源: IOP

【 摘 要 】

Okra (Abelmoschus esculentus L.) is a tropical vegetable which has been utilised for many years as panacea for various ailments, including diabetes and its associated metabolic derangements such as hyperlipidemia. Quercetin, a major flavonoid compound found in okra, has previously been reported to ameliorate lipid profile and inflammatory status. This study was carried out to investigate the effect of okra extracts on lipid profile and hs-CRP levels in animal model. Eight-week-old male Sprague Dawley rats were injected with streptozotocin (50 mg/kg) to induce type 2 diabetes. Quercetin (5 and 10 mg/kg BW) from methanolic extract of green and purple okra were subsequently administered for two consecutive weeks. Results showed that the raised concentration of total cholesterol (TC), triglycerides (TG), and LDL-cholesterol (LDL-C) were reduced in diabetic rats receiving either green or purple okra extracts compared to diabetic control group. Based on this study, it can be suggested that okra has the potential to act as a lipid-lowering agent in treating hyperlipidemia.