Effects of butter from mountain-pasture grazing cows on risk markers of the metabolic syndrome compared with conventional Danish butter: a randomized controlled study

Lipids in Health and Disease

Tine Tholstrup¹  Tue Drachmann²  Rikke A Petersen¹  Søren K Jensen³  Marianne Raff¹  Lars I Hellgren²  Louise B Werner¹ 

[1] Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Frederiksberg 1958, Denmark;Center for Biological Sequence Analysis, DTU Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark;Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, Aarhus University, 8830 Tjele, Denmark

关键词: Oral glucose tolerance test;    LDL cholesterol;    Phytanic acid;    Low-input system;    Dairy-fat;   

Others  :  834548
DOI  :  10.1186/1476-511X-12-99

 received in 2013-03-01, accepted in 2013-06-28,  发布年份 2013

【 摘 要 】

Background

There is considerable interest in dairy products from low-input systems, such as mountain-pasture grazing cows, because these products are believed to be healthier than products from high-input conventional systems. This may be due to a higher content of bioactive components, such as phytanic acid, a PPAR-agonist derived from chlorophyll. However, the effects of such products on human health have been poorly investigated.

Objective

To compare the effect of milk-fat from mountain-pasture grazing cows (G) and conventionally fed cows (C) on risk markers of the metabolic syndrome.

Design

In a double-blind, randomized, 12-week, parallel intervention study, 38 healthy subjects replaced part of their habitual dietary fat intake with 39 g fat from test butter made from milk from mountain-pasture grazing cows or from cows fed conventional winter fodder. Glucose-tolerance and circulating risk markers were analysed before and after the intervention.

Results

No differences in blood lipids, lipoproteins, hsCRP, insulin, glucose or glucose-tolerance were observed. Interestingly, strong correlations between phytanic acid at baseline and total (P<0.0001) and LDL cholesterol (P=0.0001) were observed.

Conclusions

Lack of effects on blood lipids and inflammation indicates that dairy products from mountain-pasture grazing cows are not healthier than products from high-input conventional systems. Considering the strong correlation between LDL cholesterol and phytanic acid at baseline, it may be suggested that phytanic acid increases total and LDL cholesterol.

Trial registration

ClinicalTrials.gov, NCT01343589

【 授权许可】

   
2013 Werner et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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