Lipids in Health and Disease | |
Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men | |
Research | |
Kanae Karita1  Naomi Matsunaga1  Masao Yoshida1  Yutaka Takashima1  Mamoru Ishikawa2  Tadahiro Ohtsu3  Takako Shirasawa3  Naoki Shimada3  Hirotaka Ochiai3  Hiromi Hoshino3  Masayasu Hashimoto3  Akatsuki Kokaze4  Masao Satoh5  | |
[1] Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Mito Red Cross Hospital, 3-12-48 Sannomaru, 310-0011, Mito-shi, Ibaraki, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;School of Medical Technology and Health, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, 350-1241, Hidaka-shi, Saitama, Japan; | |
关键词: Cigarette smoking; Hypo-HDL cholesterolemia; Hyper-LDL cholesterolemia; Hypertriglyceridemia; Mitochondrial DNA polymorphism; Personalized preventive medicine; | |
DOI : 10.1186/1476-511X-11-97 | |
received in 2012-02-22, accepted in 2012-07-27, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
BackgroundSeveral genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.MethodsA total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.ResultsFor subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.ConclusionsThe present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
【 授权许可】
CC BY
© Kokaze et al.; licensee BioMed Central Ltd. 2012
【 预 览 】
Files | Size | Format | View |
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RO202311103701764ZK.pdf | 292KB | download |
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