Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

Lipids in Health and Disease

Research

Kanae Karita¹  Naomi Matsunaga¹  Masao Yoshida¹  Yutaka Takashima¹  Mamoru Ishikawa²  Tadahiro Ohtsu³  Takako Shirasawa³  Naoki Shimada³  Hirotaka Ochiai³  Hiromi Hoshino³  Masayasu Hashimoto³  Akatsuki Kokaze⁴  Masao Satoh⁵ 

[1] Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Mito Red Cross Hospital, 3-12-48 Sannomaru, 310-0011, Mito-shi, Ibaraki, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;School of Medical Technology and Health, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, 350-1241, Hidaka-shi, Saitama, Japan;

关键词: Cigarette smoking;    Hypo-HDL cholesterolemia;    Hyper-LDL cholesterolemia;    Hypertriglyceridemia;    Mitochondrial DNA polymorphism;    Personalized preventive medicine;   

DOI  :  10.1186/1476-511X-11-97

 received in 2012-02-22, accepted in 2012-07-27,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundSeveral genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.MethodsA total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.ResultsFor subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.ConclusionsThe present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.

【 授权许可】

CC BY   
© Kokaze et al.; licensee BioMed Central Ltd. 2012