Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

Lipids in Health and Disease

Yutaka Takashima⁴  Hiromi Hoshino¹  Masayasu Hashimoto¹  Masao Satoh³  Hirotaka Ochiai¹  Takako Shirasawa¹  Tadahiro Ohtsu¹  Naoki Shimada¹  Masao Yoshida⁴  Kanae Karita⁴  Naomi Matsunaga⁴  Mamoru Ishikawa²  Akatsuki Kokaze⁴ 

[1] Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan;Mito Red Cross Hospital, 3-12-48 Sannomaru, Mito-shi, Ibaraki, 310-0011, Japan;School of Medical Technology and Health, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan

关键词: Personalized preventive medicine;    Mitochondrial DNA polymorphism;    Hypertriglyceridemia;    Hyper-LDL cholesterolemia;    Hypo-HDL cholesterolemia;    Cigarette smoking;   

Others  :  1160239
DOI  :  10.1186/1476-511X-11-97

 received in 2012-02-22, accepted in 2012-07-27,  发布年份 2012

【 摘 要 】

Background

Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.

Methods

A total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.

Results

For subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.

Conclusions

The present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.

【 授权许可】

   
2012 Kokaze et al.; licensee BioMed Central Ltd.

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