Frequency and distribution of mixed Plasmodiumfalciparum-vivax infections in French Guiana between 2000 and 2008

Malaria Journal

Research

Lise Musset¹  Eric Legrand²  Aurélia Stefani³  Ghislaine Prevot³  Marine Ginouves³  Bernard Carme³  Vincent Veron³  Magalie Demar³  Mathieu Nacher⁴  Paul Brousse⁵  Félix Djossou⁶ 

[1] Laboratoire de Parasitologie, Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques, CNR du Paludisme, Institut Pasteur de la Guyane, Cayenne, French Guiana;Laboratoire de Parasitologie, Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques, CNR du Paludisme, Institut Pasteur de la Guyane, Cayenne, French Guiana;Research Unit of Genetics and Genomics of Insect Vectors, Institut Pasteur, Paris, France;Medicine Department, Ecosystemes Amazoniens et Pathologie Tropicale, EA 3593, Labex CEBA, University of French Guiana, Cayenne, French Guiana;Medicine Department, Ecosystemes Amazoniens et Pathologie Tropicale, EA 3593, Labex CEBA, University of French Guiana, Cayenne, French Guiana;Centre d’Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC EC 1424, Cayenne General Hospital, Cayenne, French Guiana;Pôle des Centres Délocalisés de Prévention et de Soins, Centre Hospitalier de Cayenne, Cayenne, French Guiana;Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, Cayenne, French Guiana;

关键词: Mixed infections;    Plasmodium vivax;    Plasmodium falciparum;    Treatment;    French Guiana;   

DOI  :  10.1186/s12936-015-0971-1

 received in 2015-09-10, accepted in 2015-10-27,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe two main plasmodial species in French Guiana are Plasmodium vivax and Plasmodium falciparum whose respective prevalence influences the frequency of mixed plasmodial infections. The accuracy of their diagnosis is influenced by the sensitivity of the method used, whereas neither microscopy nor rapid diagnostic tests allow a satisfactory evaluation of mixed plasmodial infections.MethodsIn the present study, the frequency of mixed infections in different part of French Guiana was determined using real time PCR, a sensitive and specific technique.ResultsFrom 400 cases of malaria initially diagnosed by microscopy, real time PCR showed that 10.75 % of the cases were mixed infections. Their prevalence varied considerably between geographical areas. The presence, in equivalent proportions, of the two plasmodial species in eastern French Guiana was associated with a much higher prevalence of mixed plasmodial infections than in western French Guiana, where the majority of the population was Duffy negative and thus resistant to vivax malaria.ConclusionClinicians must be more vigilant regarding mixed infections in co-endemic P. falciparum/P. vivax areas, in order to deliver optimal care for patients suffering from malaria. This may involve the use of rapid diagnostic tests capable of detecting mixed infections or low density single infections. This is important as French Guiana moves towards malaria elimination.

【 授权许可】

CC BY   
© Ginouves et al. 2015