Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population: a cross sectional study

BMC Infectious Diseases

Research Article

Rehana Essop¹  Maritza J Kruger²  M Faadiel Essop²  Dillan C Beukes²  Theodore A Nell³  Esme Calitz⁴ 

[1] ANOVA Health Institute, Kohler Street, 7646, Paarl, South Africa;Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Mike De Vries Building, Merriman Avenue, 7600, Stellenbosch, South Africa;Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Mike De Vries Building, Merriman Avenue, 7600, Stellenbosch, South Africa;Division of Community Health, Tygerberg Campus, 7600, Stellenbosch, South Africa;TC Newman Community Day Care Centre, 7646, Paarl, South Africa;

关键词: HIV;    Anthropometry;    Body composition;    HAART;    Peri-urban;    South Africa;   

DOI  :  10.1186/s12879-015-0836-9

 received in 2014-08-19, accepted in 2015-02-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundHighly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic diseases in the long-term, we evaluated the anthropometric profile of black HIV-infected individuals in a peri-urban setting (Western Cape, South Africa).MethodsA cross sectional study design was followed to describe the gender differences in different HAART treatment groups. HIV-positive patients (n = 44 males, n = 102 females; 20–40 years) were recruited for three groups: 1) control (HIV-positive, HAART-naïve), 2) HIV-positive (<3 years HAART), and 3) HIV-positive (>3 years HAART).ResultsAll participants underwent comprehensive anthropometric and bio-electrical impedance analyses. No significant differences were observed in the male treatment groups. HAART-naïve females are mostly overweight (73.90 ± 2.79). This is followed by a period of muscle wasting seen in the triceps skinfold (29.30 ± 2.19 vs 20.63 ± 1.83; p < 0.01), muscle mass (22.23 ± 0.46 vs 19.82 ± 0.54; p < 0.01), and fat free mass (49.40 ± 1.08 vs 44.16 ± 1.21; p < 0.01) upon HAART initiation (<3 years HAART). Thereafter all parameters measured had levels similar to that seen for the female HAART-naïve group. Females on <3 years HAART exhibited significantly decreased body cell mass (p < 0.01), protein mass (p < 0.01), muscle mass (p < 0.01), fat free mass (p < 0.01), and fat mass (p < 0.001) versus matched HAART-naïve controls. The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males.ConclusionsThis study found striking gender-based anthropometric differences in black South African HIV-positive individuals on HAART. We also conclude from this observational study that no significant differences were found in the different male treatment groups. All female body composition parameters initially showed lower values (<3 years HAART). The female treatment group (>3 years HAART) displayed values similar to that seen in the HAART-naïve group. Higher W:H ratios in females receiving longer-term HAART potentially increases their risk for the future onset of cardio-metabolic complications.

【 授权许可】

CC BY   
© Nell et al.; licensee BioMed Central. 2015