The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Malaria Journal

Review

Lydia L Lifongo¹  Fidele Ntie-Kang²  Luc Meva’a Mbaze³  Jean Claude Ndom³  Pascal Amoa Onguéné³  Wolfgang Sippl⁴ 

[1] Chemical and Bioactivity Information Centre, Department of Chemistry, Faculty of Science, University of Buea, PO Box 63, Buea, Cameroon;Chemical and Bioactivity Information Centre, Department of Chemistry, Faculty of Science, University of Buea, PO Box 63, Buea, Cameroon;Department of Pharmaceutical Sciences, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120, Halle, Saale, Germany;Department of Chemistry, Faculty of Science, University of Douala, PO Box 24157, Douala, Cameroon;Department of Pharmaceutical Sciences, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, 06120, Halle, Saale, Germany;

关键词: Africa;    Malaria;    Medicinal plants;    Natural products;    Traditional medicine;   

DOI  :  10.1186/1475-2875-13-81

 received in 2013-10-31, accepted in 2014-02-25,  发布年份 2014

来源: Springer

【 摘 要 】

Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.

【 授权许可】

Unknown   
© Ntie-Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.