Different methods for resolving overlapping UV spectra of combination medicinal dose forms of ciprofloxacin and metronidazole

BMC Chemistry

Research

Samar O. Aljazzar¹  Eslam B. Elkaeed²  Alaa Nafea³  Samar S. Elbaramawi³  Mahmoud M. Sebaiy³  Sobhy M. El-Adl³  Amr A. Mattar⁴ 

[1] Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia;Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia;Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt;Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt;Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, 11829, Badr City, Cairo, Egypt;

关键词: Ciprofloxacin;    Metronidazole;    Advanced absorbance subtraction (AAS);    Bivariate;    Ratio difference;    Spectrum subtraction;   

DOI  :  10.1186/s13065-023-01007-z

 received in 2023-04-12, accepted in 2023-07-17,  发布年份 2023

来源: Springer

【 摘 要 】

Four simple, specific, easy, precise and accurate spectrophotometric methods were developed for the first time to examine ciprofloxacin and metronidazole in combination, without having been separated beforehand by the developed methods. Ciprofloxacin and metronidazole were determined by utilizing advanced absorbance subtraction (AAS), spectrum subtraction, bivariate and ratio difference methods. Precision, repeatability, robustness, and accuracy were all determined to be within acceptable levels after each of these procedures underwent validation in accordance with ICH recommendations. Each method’s benefits and drawbacks are illustrated, and the proposed and reported methodologies were statistically compared.

【 授权许可】

CC BY   
© Springer Nature Switzerland AG 2023

【 图 表 】

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