Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Environmental Health

Research

Aurore Fayossé¹  Danièle Luce²  Christine Barul³  Isabelle Stücker⁴  Matthieu Carton⁵  Anne-Sophie Woronoff⁶  Corinne Pilorget⁷ 

[1] INSERM U 1085, Institut de Recherche en Santé, Environnement et Travail (IRSET), Pointe-à-Pitre, France;INSERM U 1085, Institut de Recherche en Santé, Environnement et Travail (IRSET), Pointe-à-Pitre, France;Address: INSERM U1085-IRSET, Faculté de Médecine, BP-145, Campus de Fouillole, 97154, Pointe-à-Pitre, France;INSERM U 1085, Institut de Recherche en Santé, Environnement et Travail (IRSET), Pointe-à-Pitre, France;Paris Saclay University, Villejuif, France;INSERM, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif, France;Paris Saclay University, Villejuif, France;INSERM, Population-based Epidemiologic Cohorts Unit, UMS 011, Villejuif, France;Registre des tumeurs du Doubs et du Territoire de Belfort CHRU, Besançon, France;The French Public Health Agency, Saint Maurice, France;Univ Lyon, Claude Bernard Lyon1 University, Ifsttar, UMRESTTE, UMR T_9405, F-69373, Lyon, France;

关键词: Cancer;    Occupation;    Solvents;    Epidemiology;   

DOI  :  10.1186/s12940-017-0286-5

 received in 2017-03-23, accepted in 2017-07-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundFew epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk.MethodsWe analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France). Occupational exposure to five chlorinated solvents (perchloroethylene [PCE], trichloroethylene [TCE], methylene chloride [MC], chloroform [CF], and carbon tetrachloride [CT]) was assessed through job-exposure matrices. Odds ratios (ORs) and confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders.ResultsWe observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, (OR = 1.81; 95% CI = 0.68 to 4.82). In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE (p for trend = 0.04). The OR was 3.86 (95% CI = 1.30 to 11.48) for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC (OR = 2.36; 95% CI = 0.98 to 5.85).ConclusionOur findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer.

【 授权许可】

CC BY   
© The Author(s). 2017