BMC Medicine | |
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study | |
Research Article | |
Eva Herrmann1  Natalie Filmann1  Albrecht Piiper2  Stefan Zeuzem2  Bernd Kronenberger2  Oliver Waidmann2  Friederike Brunner2  Lisa Kapper2  Ina Rudloff3  Heiko Mühl3  Josef Pfeilschifter3  Malte Bachmann3  | |
[1] Institut für Biostatistik und mathematische Modellierung, Klinikum der J.W. Goethe Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany;Medizinische Klinik 1, Klinikum der J.W. Goethe Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany;Pharmazentrum Frankfurt, Klinikum der J.W. Goethe Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany; | |
关键词: Interleukin-22; Liver cirrhosis; Liver-related complications; Hepatitis; Alcoholic liver disease; MELD; | |
DOI : 10.1186/1741-7015-10-102 | |
received in 2012-03-20, accepted in 2012-09-11, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
BackgroundInterleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease. Systematic analysis of serum IL-22 in relation to morbidity and mortality of patients with advanced liver cirrhosis has not been performed so far.MethodsThis is a prospective cohort study including 120 liver cirrhosis patients and 40 healthy donors to analyze systemic levels of IL-22 in relation to survival and hepatic complications.ResultsA total of 71% of patients displayed liver cirrhosis-related complications at study inclusion. A total of 23% of the patients died during a mean follow-up of 196 ± 165 days. Systemic IL-22 was detectable in 74% of patients but only in 10% of healthy donors (P < 0.001). Elevated levels of IL-22 were associated with ascites (P = 0.006), hepatorenal syndrome (P < 0.0001), and spontaneous bacterial peritonitis (P = 0.001). Patients with elevated IL-22 (>18 pg/ml, n = 57) showed significantly reduced survival compared to patients with regular (≤18 pg/ml) levels of IL-22 (321 days versus 526 days, P = 0.003). Other factors associated with reduced overall survival were high CRP (≥2.9 mg/dl, P = 0.005, hazard ratio (HR) 0.314, confidence interval (CI) (0.141 to 0.702)), elevated serum creatinine (P = 0.05, HR 0.453, CI (0.203 to 1.012)), presence of liver-related complications (P = 0.028, HR 0.258, CI (0.077 to 0.862)), model of end stage liver disease (MELD) score ≥20 (P = 0.017, HR 0.364, CI (0.159 to 0.835)) and age (P = 0.011, HR 0.955, CI (0.922 to 0.989)). Adjusted multivariate Cox proportional-hazards analysis identified elevated systemic IL-22 levels as independent predictors of reduced survival (P = 0.007, HR 0.218, CI (0.072 to 0.662)).ConclusionsIn patients with liver cirrhosis, elevated systemic IL-22 levels are predictive for reduced survival independently from age, liver-related complications, CRP, creatinine and the MELD score. Thus, processes that lead to a rise in systemic interleukin-22 may be relevant for prognosis of advanced liver cirrhosis.
【 授权许可】
CC BY
© Kronenberger et al; licensee BioMed Central Ltd. 2012
【 预 览 】
Files | Size | Format | View |
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RO202311102471562ZK.pdf | 1381KB | download |
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