BMC Medicine | |
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study | |
关键词: Interleukin-22; Liver cirrhosis; Liver-related complications; Hepatitis; Alcoholic liver disease; MELD; | |
DOI : 10.1186/1741-7015-10-102 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease. Systematic analysis of serum IL-22 in relation to morbidity and mortality of patients with advanced liver cirrhosis has not been performed so far.
Methods
This is a prospective cohort study including 120 liver cirrhosis patients and 40 healthy donors to analyze systemic levels of IL-22 in relation to survival and hepatic complications.
Results
A total of 71% of patients displayed liver cirrhosis-related complications at study inclusion. A total of 23% of the patients died during a mean follow-up of 196 ± 165 days. Systemic IL-22 was detectable in 74% of patients but only in 10% of healthy donors (
Conclusions
In patients with liver cirrhosis, elevated systemic IL-22 levels are predictive for reduced survival independently from age, liver-related complications, CRP, creatinine and the MELD score. Thus, processes that lead to a rise in systemic interleukin-22 may be relevant for prognosis of advanced liver cirrhosis.
【 授权许可】
Unknown