Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE

Environmental Health

Research

Alan A. Cohen¹  Jean-Charles Pasquier²  Larissa Takser³  Nadia Abdelouahab³  Yasmine K. Serme-Gbedo³ 

[1] Department of Family Medicine, PRIMUS Research Group, University of Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, Québec, Canada;Department of Gynecology and Obstetrics, Faculty of Medicine, University of Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, Quebec, Canada;Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, 3001 12e Avenue Nord, J1H 5N4, Sherbrooke, Quebec, Canada;

关键词: Polybrominated diphenyl ethers;    Pregnancy;    Birth weight;    Polychlorinated biphenyls;    Mercury;    Lead;    Cadmium;    Manganese;   

DOI  :  10.1186/s12940-016-0134-z

 received in 2015-08-31, accepted in 2016-04-03,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPolybrominated diphenyl ethers are known endocrine disrupting environmental contaminants used as flame retardants. Their levels have increased in humans over the last ten years, raising concerns about their consequences on human health. Some animal studies suggest that PBDEs can affect fetal growth; however, the results of human studies are contradictory. This study evaluates the association between the most common PBDEs in maternal blood measured in early pregnancy and birth weight.MethodsBDE-47, BDE-99, BDE-100 and BDE-153 levels were measured in 349 women during their first prenatal care visit at the University Hospital Center of Sherbrooke (Quebec, Canada). Birth weight and relevant medical information were collected from medical records. In contrast with previous studies, we examined the full range of clinical risk factors known to affect fetal growth as potential confounders, as well as other environmental pollutants that are likely to interact with fetal growth (polychlorinated biphenyls (PCBs), mercury, lead, cadmium and manganese).ResultsThere was no statistically significant relationship between PBDE levels in early pregnancy and birth weight in both unadjusted and multivariate regression models.ConclusionsOur results suggest that PBDEs in early pregnancy have little or no direct impact on birth weight, at least at the levels of exposure in our population.

【 授权许可】

CC BY   
© Serme-Gbedo et al. 2016