Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project

BMC Neurology

Study Protocol

S. Guggsa¹  O. Agabi²  N. Okubadejo²  O. Ojo³  J. Kwasa⁴  F. O. Nwaokorie⁵  A. Shalash⁶  D. Mushi⁷  M. C. J. Dekker⁸  S. Urasa⁸  J. Rogathi⁸  F. S. Sarfo⁹  S. Kariuki^1,10  R. Walker^1,11  C. Dotchin^1,11  R. Cilia^1,12  T. Park^1,13  N. Fothergill-Misbah^1,14  M. Breckons^1,14  L. Ternent^1,14  M. Cham^1,15  L. Rochester^1,16  S. Del Din^1,16  A. Akpalu^1,17  F. Amod^1,18 

[1] Addis Ababa University, Addis Ababa, Ethiopia;College of Medicine, University of Lagos, Lagos, Nigeria;College of Medicine, University of Lagos, Lagos, Nigeria;Lagos University Teaching Hospital, Lagos, Nigeria;Department of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya;Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria;Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt;Institute of Public Health, Kilimanjaro Christian Medical University College, Moshi, Tanzania;Kilimanjaro Christian Medical Centre, Moshi, Tanzania;Kilimanjaro Christian Medical University College, Moshi, Tanzania;Kwame Nkrumah University of Science & Technology, Kumasi, Ghana;Neuroscience Unit, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya;Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne, UK;Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK;Parkinson and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;Parkinson’s Africa, Kingston upon Thames, UK;Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK;Richard Novati Catholic Hospital, Sogakope, Ghana;Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK;National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK;University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana;University of KwaZulu-Natal, Durban, South Africa;

关键词: Parkinson’s disease;    Africa;    Diagnosis;    Treatment;    Epidemiology;    Microbiome;    Metabolome;    Pesticides;    Genetics;    Prevalence;   

DOI  :  10.1186/s12883-023-03414-0

 received in 2023-06-13, accepted in 2023-09-29,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundParkinson’s disease (PD) is the second most common neurodegenerative disorder and, according to the Global Burden of Disease estimates in 2015, was the fastest growing neurological disorder globally with respect to associated prevalence, disability, and deaths. Information regarding the awareness, diagnosis, phenotypic characteristics, epidemiology, prevalence, risk factors, treatment, economic impact and lived experiences of people with PD from the African perspective is relatively sparse in contrast to the developed world, and much remains to be learned from, and about, the continent.MethodsTransforming Parkinson’s Care in Africa (TraPCAf) is a multi-faceted, mixed-methods, multi-national research grant. The study design includes multiple sub-studies, combining observational (qualitative and quantitative) approaches for the epidemiological, clinical, risk factor and lived experience components, as appropriate, and interventional methods (clinical trial component). The aim of TraPCAf is to describe and gain a better understanding of the current situation of PD in Africa. The countries included in this National Institute for Health and Care Research (NIHR) Global Health Research Group (Egypt, Ethiopia, Ghana, Kenya, Nigeria, South Africa and Tanzania) represent diverse African geographies and genetic profiles, with differing resources, healthcare systems, health and social protection schemes, and policies. The research team is composed of experts in the field with vast experience in PD, jointly led by a UK-based and Africa-based investigator.DiscussionDespite the increasing prevalence of PD globally, robust data on the disease from Africa are lacking. Existing data point towards the poor awareness of PD and other neurological disorders on the continent and subsequent challenges with stigma, and limited access to affordable services and medication. This multi-site study will be the first of its kind in Africa. The data collected across the proposed sub-studies will provide novel and conclusive insights into the situation of PD. The selected country sites will allow for useful comparisons and make results relevant to other low- and middle-income countries. This grant is timely, as global recognition of PD and the public health challenge it poses builds. The work will contribute to broader initiatives, including the World Health Organization’s Intersectoral global action plan on epilepsy and other neurological disorders.Trial registrationhttps://doi.org/10.1186/ISRCTN77014546.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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