Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy

BMC Cardiovascular Disorders

Research Article

Hui Chen¹  Guodong Ma¹  Wenying Ma¹  Aidong Shen¹  Xinheng Feng²  Zhaoping Li²  Jieli Feng²  Hongyan Wang²  Baoxia Chen²  Wei Gao²  Weihong Li²  Yongzhen Zhang²  Ming Xu³ 

[1] Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, 100050, Beijing, China;Department of Cardiology, Peking University Third Hospital, 100191, Beijing, China;Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, 100191, Beijing, China;

关键词: Tissue Doppler imaging;    Heart failure with normal ejection fraction;    Non-obstructive hypertrophic cardiomyopathy;    Cardiopulmonary exercise testing;    N-terminal pro-brain natriuretic peptide;   

DOI  :  10.1186/1471-2261-14-194

 received in 2014-01-21, accepted in 2014-06-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundHypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET).MethodTwenty-seven non-obstructive HCM patients and 31 age- and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were analyzed before and after exercise.ResultFive HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.ConclusionElevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.

【 授权许可】

Unknown   
© Ma et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.