Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy

BMC Cardiovascular Disorders

Yongzhen Zhang¹  Xinheng Feng¹  Aidong Shen²  Hui Chen²  Wenying Ma²  Hongyan Wang¹  Jieli Feng¹  Baoxia Chen¹  Weihong Li¹  Zhaoping Li¹  Wei Gao¹  Ming Xu³  Guodong Ma² 

[1] Department of Cardiology, Peking University Third Hospital, 100191 Beijing, China;Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China;Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, 100191 Beijing, China

关键词: N-terminal pro-brain natriuretic peptide;    Cardiopulmonary exercise testing;    Non-obstructive hypertrophic cardiomyopathy;    Heart failure with normal ejection fraction;    Tissue Doppler imaging;   

Others  :  1088398
DOI  :  10.1186/1471-2261-14-194

 received in 2014-01-21, accepted in 2014-06-23,  发布年份 2014

【 摘 要 】

Background

Hypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET).

Method

Twenty-seven non-obstructive HCM patients and 31 age- and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were analyzed before and after exercise.

Result

Five HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.

Conclusion

Elevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.

【 授权许可】

   
2014 Ma et al.; licensee BioMed Central.

【 图 表 】

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