BMC Cardiovascular Disorders | |
Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy | |
Research Article | |
Hui Chen1  Guodong Ma1  Wenying Ma1  Aidong Shen1  Xinheng Feng2  Zhaoping Li2  Jieli Feng2  Hongyan Wang2  Baoxia Chen2  Wei Gao2  Weihong Li2  Yongzhen Zhang2  Ming Xu3  | |
[1] Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, 100050, Beijing, China;Department of Cardiology, Peking University Third Hospital, 100191, Beijing, China;Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, 100191, Beijing, China; | |
关键词: Tissue Doppler imaging; Heart failure with normal ejection fraction; Non-obstructive hypertrophic cardiomyopathy; Cardiopulmonary exercise testing; N-terminal pro-brain natriuretic peptide; | |
DOI : 10.1186/1471-2261-14-194 | |
received in 2014-01-21, accepted in 2014-06-23, 发布年份 2014 | |
来源: Springer | |
【 摘 要 】
BackgroundHypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET).MethodTwenty-seven non-obstructive HCM patients and 31 age- and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were analyzed before and after exercise.ResultFive HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.ConclusionElevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.
【 授权许可】
Unknown
© Ma et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
【 预 览 】
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