Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study

Environmental Health

Research

Hui Tan¹  De-Kun Li²  Hong Liang³  Maohua Miao³  Wei Yuan³  Ziliang Wang⁴  Zhijun Zhou⁵  Xiaoqin Liu⁶ 

[1] Department of Child and Adolescent Health, School of Public Health, Fudan University, 200032, Shanghai, China;Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 94612, Oakland, CA, USA;Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, 779 Old Humin Road, 200237, Shanghai, China;Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, 779 Old Humin Road, 200237, Shanghai, China;School of Public Health, Fudan University, 200032, Shanghai, China;School of Public Health, Key Laboratory for Public Health Safety, Fudan University, 200032, Shanghai, China;The National Centre for Register-based Research, Aarhus university, 8000, Aarhus, Denmark;

关键词: Bisphenol A;    Endocrine disruptor;    Girl;    Puberty;    Tanner stage;   

DOI  :  10.1186/s12940-017-0290-9

 received in 2017-01-10, accepted in 2017-07-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAnimal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.MethodsThis was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).ResultsAfter adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.ConclusionsBPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.

【 授权许可】

CC BY   
© The Author(s). 2017