If the wheel ain’t broke, don’t reinvent it

Lipids in Health and Disease

Commentary

Pauli Ohukainen¹ 

[1] Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland;

关键词: Cholesterol;    Mevalonate;    Hypothesis;   

DOI  :  10.1186/1476-511X-12-51

 received in 2013-02-15, accepted in 2013-03-27,  发布年份 2013

来源: Springer

【 摘 要 】

During the past 100 years, several theories explaining human atherosclerosis have been postulated and tested. More than anything else, experimental and observational evidence has supported a very strong causal role for dyslipidemia. This has been established as the current paradigm in both biomedical research as well as public health policies. Recently, a novel hypothesis for the etiology of atherosclerosis was presented. The purpose of this commentary is to critically evaluate its validity.

【 授权许可】

CC BY   
© Ohukainen; licensee BioMed Central Ltd. 2013