The anaemia of Plasmodium vivax malaria

Malaria Journal

Review

Nicholas J White¹  Ric N Price²  Nicholas M Douglas²  Nicholas M Anstey³  Tsin W Yeo³  Jeanne R Poespoprodjo⁴  Pierre A Buffet⁵ 

[1] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK;Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Global Health Division, Menzies School of Health Research, PO Box 41096, 0811, Casuarina, NT, Australia;Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK;Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia;Global Health Division, Menzies School of Health Research, PO Box 41096, 0811, Casuarina, NT, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia;Global Health Division, Menzies School of Health Research, PO Box 41096, 0811, Casuarina, NT, Australia;Mimika District Health Authority, Timika, Papua, Indonesia;Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;INSERM - UPMC, (Paris 6 University) UMRs945, F-75013, Paris, France;Department of Parasitology, Pitié-Salpétrière Hospital, Assistance Publique – Hôpitaux de Paris, F-75013, Paris, France;Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Département de Parasitologie Mycologie, F-75015, Paris, France;

关键词: Plasmodium vivax;    Malaria;    Anaemia;    Epidemiology;    Pathogenesis;   

DOI  :  10.1186/1475-2875-11-135

 received in 2012-02-19, accepted in 2012-04-17,  发布年份 2012

来源: Springer

【 摘 要 】

Plasmodium vivax threatens nearly half the world’s population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia. This review synthesizes current evidence on the epidemiology, pathogenesis, treatment and consequences of vivax-associated anaemia. Young children are at high risk of clinically significant and potentially severe vivax-associated anaemia, particularly in countries where transmission is intense and relapses are frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium vivax causes similar absolute reduction in red blood cell mass because it results in proportionately greater removal of uninfected red blood cells. Severe vivax anaemia is associated with substantial indirect mortality and morbidity through impaired resilience to co-morbidities, obstetric complications and requirement for blood transfusion. Anaemia can be averted by early and effective anti-malarial treatment.

【 授权许可】

CC BY   
© Douglas et al.; licensee BioMed Central Ltd. 2012