Cow’s milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT

Nutrition Journal

Research

I. R. Almeida¹  M. V. Pontes¹  T. C. M. Ribeiro¹  V. M. Leal¹  H. Ribeiro¹  G. N. Cabral¹  A. P. de Mattos¹  D. M. F. Scalabrin²  S. Stolz²  W. Zhuang² 

[1] Federal University of Bahia, Salvador, Bahia, Brazil;Mead Johnson Pediatric Nutrition Institute, Evansville, IN, USA;

关键词: DHA;    Prebiotics;    Yeast β-glucan;    Allergic manifestations;    Children;   

DOI  :  10.1186/s12937-016-0138-0

 received in 2015-11-10, accepted in 2016-02-18,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundNutrients such as docosahexaenoic acid (DHA), prebiotics and β-glucan have been associated with reduced incidence of respiratory illnesses and allergic manifestations (AM). Our objective was to assess if consumption of a cow’s milk-based beverage with these and other nutrients supports respiratory, gastrointestinal, and skin health in otherwise well-nourished, healthy children.MethodsIn this double-blind, randomized, controlled trial, healthy children (1–4 years of age) from two daycare centers in Brazil were fed three servings/day of a cow’s milk-based beverage (CMBB; n = 125) containing DHA, the prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), β-glucan, and other key nutrients, or a control cow’s milk-based beverage (control; n = 131) for up to 28 weeks. Occurrence of respiratory infections, diarrheal disease and AM was assessed by study pediatricians and the number of episodes were analyzed with the Cochran-Mantel-Haenszel test and the Andersen-Gill model.ResultsThe CMBB group had fewer episodes of AM, which included allergic rhinitis or conjunctivitis, wheezing, allergic cough, eczema and urticaria, compared to the control group (p = 0.021). The hazard ratio for increased number of episodes of AM was lower in the CMBB group compared to control (HR, 0.64; 95 % CI 0.47–0.89; p = 0.007). There was no difference in the incidence of respiratory infections and diarrheal disease between groups.ConclusionA cow’s milk-based beverage containing DHA, PDX/GOS, and yeast β-glucan, and supplemented with micronutrients, including zinc, vitamin A and iron, when consumed 3 times/day for 28 weeks by healthy 1- to 4-year-old children was associated with fewer episodes of allergic manifestations in the skin and the respiratory tract.Trial registrationregistration number: NCT01431469

【 授权许可】

CC BY   
© Pontes et al. 2016