Oral administration of yeast β-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis

Journal of Functional Foods

Jianzhong Han¹  Ming Yao²  Feifei Han²  Shasha Yang²  Hanxue Fan² 

[1] Corresponding author.;Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China;

关键词: Inflammation;    Intestinal barrier;    Tight junction;    Colitis;    Yeast β-glucan;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ulcerative colitis is a chronic inflammatory disease that is characterized by relapsing inflammation and dysfunction within the gastrointestinal tract. The purpose of this study was to investigate the protective effects of yeast β-glucan on regulating inflammation and disruption of the epithelial barrier in colitis caused by dextran sulfate sodium (DSS). Oral administration of yeast β-glucan reduced clinical symptoms, inflammatory infiltrates and cell apoptosis in the colon epithelium, ameliorated intestinal permeability and the structural integrity of tight junctions. Moreover, treatment with yeast β-glucan not only decreased myeloperoxidase, eosinophil peroxidase and N-acetyl-β-d-glucosaminidase levels, but also modified the immune status characterized by the change in immunoglobulin levels in DSS-treated mice. These results suggest that yeast β-glucan improves DSS-induced changes in mucosal inflammatory lesions and the intestinal barrier by inhibiting the expression of inflammatory mediators and enhancing the expression of tight junction proteins associated with intestinal permeability.

【 授权许可】

Unknown