Relationship key factor of inflammation and the development of complications in the late period of myocardial infarction in patients with visceral obesity

BMC Cardiovascular Disorders

Research Article

Olga Akbasheva¹  Evgenya Uchasova²  Victoria Karetnikova²  Alexander Kokov²  Vera Matveeva²  Olga Gruzdeva²  Yulia Dyleva²  Olga Barbarash² 

[1] Federal State Budget Educational Institution of Higher Professional Education “Siberian State Medical University” of the Ministry of Healthcare of the Russian Federation, Tomsk, Russia;Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Disease”, Kemerovo, Russia;

关键词: Myocardial Infarction;    Proinflammatory Cytokine;    Visceral Adipose Tissue;    Subcutaneous Adipose Tissue;    Adverse Cardiovascular Event;   

DOI  :  10.1186/s12872-017-0473-x

 received in 2016-08-22, accepted in 2017-01-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCytokines play an significant role in regulating non-specific inflammatory response involved in many pathological processes. The current study tested the hypothesis that myocardial infarction in patients with obesity can lead to increased production of proinflammatory cytokines and unfavorable course of the pathological process.MethodsThe study recruited 232 male patients with ST-elevated myocardial infarction. The mean age of the patients was 58.7 (52.2-69.9) years. All the patients were assigned to two groups according to the computed tomography findings: 1 (n = 160) patients with visceral obesity (VO), and 2 (n = 72) patients without VO. Interleukins were measured in blood serum on days 1 and 12 after MI.ResultsAll patients with MI demonstrated elevated levels of proinflammatory markers and reduced anti-inflammatory markers in the in-hospital period. The results suggested that among all studied inflammatory markers IL-6 (OR 1.9; 95% CI (1.6–2.8) and CRP (OR 1.3; 95% CI (1.1–1.8) were closely related to VO. One year after MI adverse cardiovascular outcome frequently occurred in patients with VO. There were two cardiac deaths (3.1%), 6 cases (9.3%) of recurrent MI, 19 cases (29.6%) of repeated hospitalizations for unstable angina, whereas only 2 patients without VO (6.6%) were hospitalized for unstable angina. The results of the logistic regression analysis demonstrated that IL-6, IL-12, and IL-10 had the highest predictive value for occurrence of adverse cardiovascular events in patients with VO.ConclusionCytokine profile in MI patients with VO is characterized by an imbalance caused by elevated pro-inflammatory interleukins and decreased anti-inflammatory interleukins. Obesity in patients was associated with a marked increase in IL-6 and CRP levels.

【 授权许可】

CC BY   
© The Author(s). 2017