Green synthesis of gold nanoparticles and their anticancer activity

Cancer Nanotechnology

Original Paper

Kasivelu Govindaraju¹  Mohamed Sadiq²  Ganesan Singaravelu³  Ravi Geetha³  Thirunavukkarasu Ashokkumar³  Selvaraj Tamilselvan³ 

[1] Centre for Ocean Research, Sathyabama University, 600 119, Chennai, India;Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai, Tamilnadu, India;Nanoscience Division, Department of Zoology, Thiruvalluvar University, 632 115, Vellore, India;

关键词: Couroupita guianensis;    Gold nanoparticles;    Anticancer;    DNA fragmentation;   

DOI  :  10.1007/s12645-013-0040-9

 received in 2013-03-21, accepted in 2013-05-05,  发布年份 2013

来源: Springer

【 摘 要 】

As the nano revolution unfolds, it is imperative to integrate nanoscience and medicine. The secret gleaned from nature have led to the generation of biogenic technologies for the fabrication of advanced nanomaterials. Present investigation discloses the gold nanoparticles biosynthesizing capability of the flower of pharmacologically important tree Couroupita guianensis. Rapid, cost-effective, one-step process of synthesis has been achieved. Newly genre gold nanoparticles were characterized by involving UV–vis spectroscopy, FTIR, XRD, SEM, and TEM analysis. Interestingly, as a result of extensive screening on the application of newly synthesized gold nanoparticles their anticancer potential has been discovered using MTT assay, DNA fragmentation, apoptosis by DAPI staining, and comet assay for DNA damage.

【 授权许可】

Unknown   
© Springer-Verlag Wien 2013