Tracking of stem cells in vivo for cardiovascular applications

Journal of Cardiovascular Magnetic Resonance

Review

Yingli Fu¹  Jeremy Maurer¹  Nicole Azene²  Dara L Kraitchman³ 

[1] Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, USA;Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, USA;Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, MD, USA;Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, USA;Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, MD, USA;Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 314 Park Building, 21287, Baltimore, MD, USA;

关键词: Cell tracking;    Cell labeling;    Stem cells;    Cardiovascular disease;    Computed tomography;    Fluoroscopy;    Cardiovascular magnetic resonance;    Radionuclide imaging;    Optical imaging;    Ultrasound;    Image-guided therapy;   

DOI  :  10.1186/1532-429X-16-7

 received in 2012-12-16, accepted in 2013-12-11,  发布年份 2014

来源: Springer

【 摘 要 】

In the past ten years, the concept of injecting stem and progenitor cells to assist with rebuilding damaged blood vessels and myocardial tissue after injury in the heart and peripheral vasculature has moved from bench to bedside. Non-invasive imaging can not only provide a means to assess cardiac repair and, thereby, cellular therapy efficacy but also a means to confirm cell delivery and engraftment after administration. In this first of a two-part review, we will review the different types of cellular labeling techniques and the application of these techniques in cardiovascular magnetic resonance and ultrasound. In addition, we provide a synopsis of the cardiac cellular clinical trials that have been performed to-date.

【 授权许可】

Unknown   
© Azene et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.