Development and validation of a condition-specific diary to measure severity, bothersomeness and impact on daily activities for patients with acute urinary tract infection in primary care

Health and Quality of Life Outcomes

Research

Anne Holm¹  Gloria Cordoba¹  Volkert Siersma¹  John Brodersen¹ 

[1] Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, PO box 2099, Øster Farimagsgade 5, 1014, Copenhagen, Denmark;

关键词: Urinary tract infections;    Cystitis;    Validation studies;    Psychometrics;    Item-response theory;    Rasch analysis;    Patient-reported outcomes;    Patient-reported outcome measures;    PROM;    Primary care;   

DOI  :  10.1186/s12955-017-0629-5

 received in 2016-11-04, accepted in 2017-03-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundUrinary tract infection (UTI) is a common condition in primary care. Patient-reported outcome measures (PROMs) are crucial in the evaluation of interventions to improve diagnosis, treatment and prognosis of UTI. The aim of this study was to identify an existing condition-specific PROM to measure symptom severity, bothersomeness and impact on daily activities for adult patients with suspected urinary tract infection in primary care; or, in the absence of such a PROM, to test items identified from existing PROMs for coverage and relevance in single and group interviews and to psychometrically validate the resulting PROM.MethodsThe literature was searched for existing PROMs covering the three domains. Items from the identified PROMs were tested in single and group interviews. The resulting symptom diary was psychometrically validated using the partial credit Rasch model for polytomous items in a cohort of 451 women participating in two studies regarding UTI.ResultsNo existing PROM fulfilled the inclusion criteria. Content validation resulted in one domain concerning symptom severity (18 items), one concerning bothersomeness (18 items), and one concerning impact on daily activities (7 items). Psychometrical validation resulted in four dimensions in each of the first two domains and one dimension in the third domain.ConclusionsDomains were not unidimensional, which meant that we identified dimensions of patient-experienced UTI that differed substantially from those previously found. We recommend that future studies on UTI, in which PROMs are to be used, should ensure high content validity of their outcome measures and unidimensionality of the included dimensions.

【 授权许可】

CC BY   
© The Author(s). 2017