Urinary glicosaminoglycans levels in women with urinary tract infection and non urinary tract infection

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Pasaribu, H.P.^1 ; Hanifa, A.^1 ; Tala, R.Z.^1 ; Ardiansyah, E.^1 ; Simanjuntak, R.Y.^1 ; Effendy, I.H.^1

Department of Obstetrics and Gynecology, Haji Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

关键词: Defense mechanism;    Glycosaminoglycans;    Odds ratios;    Thin layers;    Urinary glycosaminoglycans;    Urinary tract;    Urinary tract infections;    Urine sample;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012046/pdf
DOI  :  10.1088/1755-1315/125/1/012046

来源: IOP

【 摘 要 】

UTI is an infection that occurs in the urinary tract due to the proliferation of a microorganism. Female is fourteen times more vulnerable to UTI than male, because their urethra is shorter. Bladder epithelium is coated with a thin layer of glycosaminoglycans which act as a non-specific anti-adherence factor and nonspecific defense mechanisms against infection and can be found in the urine. An analytic study with cross sectional approach was conducted in 46 patients (23 with UTI and 23 non UTI) from June 2016 to determine differences in levels of urinary glycosaminoglycans between two groups. Urine samples were taken and tested for UTI and non UTI strips test. Laboratory examination of urine GAGs levels using ELISA kit for Human Glycosaminoglycans, then tabulated and analyzed using SPSS. The result showed no significant differences in the characteristics of women between two groups. There are significant differences in the mean levels of urinary GAGs in women with UTI compared with Non-UTI (69.74 ± 21.34; 21.39 ± 2.61 mg/l; p