Mentzer Index Diagnostic Value in Predicting Thalassemia Diagnosis

1st International Conference on Life and Applied Sciences for Sustainable Rural Development

生态环境科学

Siswandari, W.^1 ; Rujito, L.^1 ; Indriani, V.^1 ; Djatmiko, W.^1

Medical Faculty, Universitas Jenderal Soedirman, Purwokerto, Indonesia^1

关键词: Diagnostic value;    Mentzer Index;    Negative predictive value;    Odds ratios;    Positive predictive values;    thalassemia;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/255/1/012004/pdf
DOI  :  10.1088/1755-1315/255/1/012004

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Thalassemia diagnosis requires gen examination using Polymerase Chain Reaction (PCR) device or hemoglobin (Hb) electrophoresis using electrophoresis or High Performance Liquid Chromatography (HPLC) device which is only available in certain hospitals. Therefore, it is important to develop easily examined parameters which are useful to assess thalassemia carrier diagnosis. This study aims at figuring out the diagnostic value of Mentzer Index in predicting beta-thalassemia carrier compared to the results of HB electrophoresis examination. Data were taken from 37 anemia patients at Prof. Dr. Margono Soekarjo Regional Public Hospital in Purwokerto who underwent Hb electrophoresis examination using electrophoresis instrument and routine blood count. Furthermore, Mentzer Index was calculated, odds ratio (OR) was analyzed, and diagnostic values were compared to the results of Hb electrophoresis. Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier.