Exploration of Fungal Association From Hard Coral Against Pathogen MDR Staphylococcus haemolyticus

2nd International Conference on Tropical and Coastal Region Eco Development 2016

地球科学;生态环境科学

Cristianawati, O.^1 ; Radjasa, O.K.^2,3 ; Sabdono, A.^3 ; Trianto, A.^3 ; Sabdaningsih, A.^1 ; Sibero, M.T.^1 ; Nuryadi, H.^4

Coastal Resources Management, Diponegoro University, Semarang

50241, Indonesia^1

Ministry of Research, Technology and Higher Education, Indonesia^2

Department of Marine Science, Diponegoro University, Semarang

50241, Indonesia^3

UPT Laboratorium Terpadu, Diponegoro University, Semarang

50241, Indonesia^4

关键词: Marine invertebrates;    Marine natural products;    Molecular identification;    Phylogenetic diversity;    Secondary metabolites;    Staphylococcus haemolyticus;    Trichoderma longibrachiatum;    Urinary tract infections;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/55/1/012027/pdf
DOI  :  10.1088/1755-1315/55/1/012027

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Staphylococcus haemolyticus are opportunistic bacteria and as the second leading cause of nosocomial infections. It is a disease causing septicemia, peritonitis, otitis, and urinary tract infections and infections of the eye. It also a phenotype resistant to multiple antibiotics commercial. There is now an urgency to find an alternative antibiotics to combat this bacteria. It has been widely reported that many bioactive marine natural products from marine invertebrate have striking similarities to metabolites of their associated microorganisms including fungi. Hard coral associated microorganisms are among of the most interesting and promising marine natural product sources, which produce with various biological activities. The proposed work focused on the discovery of bioactive compounds and also estimated the phylogenetic diversity from fungal association of hard coral against pathogen MDR Staphylococcus haemolyticus. A total of 32 fungal association, FHP 7 which were isolated from Favia sp. capable of inhibiting the growth MDR. Molecular identification based on 18S rRNA gene sequences revealed that the active fungal association belonged 100% to the members from one of the genera Trichoderma longibrachiatum. Accession Number LC185084.1.