Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance

World Journal of Surgical Oncology

Research

Pei Zhang¹  Yuan Yuan Zhang¹  Zhen Hua Chao¹  Qian Wen Zhang¹  Fang Wang²  Fei Xia²  Jin Cheng Xu² 

[1] Department of Pharmacy, Bengbu Medical College, No 2600, East Sea Road, 233000, Bengbu, Anhui, People’s Republic of China;Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, No 287, Chang-Huai Road, 233000, Bengbu, Anhui, People’s Republic of China;

关键词: Glucose-related proteins 78;    Heparanase;    Immunohistochemistry;    Oral squamous cell carcinoma;    Prognosis;   

DOI  :  10.1186/1477-7819-12-121

 received in 2013-06-23, accepted in 2014-04-07,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival.MethodsA total of 46 patients with OSCC and 10 normal individuals were recruited for the study. GRP78 and HPA expression were determined in the lesion tissues using immunohistochemical analysis. The correlation between GRP78 and HPA was assessed using the Spearman correlation analysis. The associations of GRP78 and HPA with clinicopathological characteristics and survival were examined using the x2-test, Kaplan–Meier, or Cox regression.ResultsPatients with OSCC showed a statistically significant higher prevalence of GRP78 and HPA expression than normal oral tissues. GRP78 and HPA expression was positively correlated with size, TNM stage, histological grade, lymphatic metastasis, and distant metastasis in OSCC patients. GRP78 expression was also positively correlated with HPA expression. Positive GRP78 and HPA expression was inversely correlated with survival in OSCC patients.ConclusionsHPA expression was found to be positively correlated with GRP78 expression. GRP78 and HPA are biomarkers that may have the potential to guide the treatment of oral cancer patients.

【 授权许可】

Unknown   
© Xia et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.