The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma

European Journal of Medical Research

Tong Su³  Kun Xia²  Tengfei Zhu²  Qiong Liu²  Lu Lin³  Jingmin You¹ 

[1] Department of Stomatology, First People’s Hospital of Changde, Changde 415003 Hunan, China;State Key Laboratory of Medical Genetics, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China;Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha 410008, China

关键词: Recurrence;    Real-time polymerase chain reaction;    Oral squamous cell carcinoma;    Metastasis;    Immunohistochemistry;    Differentiated embryo-chondrocyte expressed gene l;   

Others  :  817443
DOI  :  10.1186/2047-783X-19-21

 received in 2013-12-02, accepted in 2014-03-31,  发布年份 2014

【 摘 要 】

Background

This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC.

Methods

The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively.

Results

The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P <0.05); further, the expression of DEC1 in different OSCC groups was statistically significant (P <0.05). The expression of DEC1 in the 1-year recurrence OSCC group was significantly higher than other groups. The expression of DEC1 in the 3-years no recurrence OSCC group was the lowest.

Conclusions

The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.

【 授权许可】

   
2014 You et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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