Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance

World Journal of Surgical Oncology

Fang Wang¹  Zhen Hua Chao²  Qian Wen Zhang²  Yuan Yuan Zhang²  Pei Zhang²  Jin Cheng Xu¹  Fei Xia¹ 

[1] Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, No 287, Chang-Huai Road, Bengbu 233000, Anhui, People’s Republic of China;Department of Pharmacy, Bengbu Medical College, No 2600, East Sea Road, Bengbu 233000, Anhui, People’s Republic of China

关键词: Prognosis;    Oral squamous cell carcinoma;    Immunohistochemistry;    Heparanase;    Glucose-related proteins 78;   

Others  :  819739
DOI  :  10.1186/1477-7819-12-121

 received in 2013-06-23, accepted in 2014-04-07,  发布年份 2014

【 摘 要 】

Background

The aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival.

Methods

A total of 46 patients with OSCC and 10 normal individuals were recruited for the study. GRP78 and HPA expression were determined in the lesion tissues using immunohistochemical analysis. The correlation between GRP78 and HPA was assessed using the Spearman correlation analysis. The associations of GRP78 and HPA with clinicopathological characteristics and survival were examined using the x²-test, Kaplan–Meier, or Cox regression.

Results

Patients with OSCC showed a statistically significant higher prevalence of GRP78 and HPA expression than normal oral tissues. GRP78 and HPA expression was positively correlated with size, TNM stage, histological grade, lymphatic metastasis, and distant metastasis in OSCC patients. GRP78 expression was also positively correlated with HPA expression. Positive GRP78 and HPA expression was inversely correlated with survival in OSCC patients.

Conclusions

HPA expression was found to be positively correlated with GRP78 expression. GRP78 and HPA are biomarkers that may have the potential to guide the treatment of oral cancer patients.

【 授权许可】

   
2014 Xia et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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