High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Cardiovascular Diabetology

Original Investigation

Koji Yanagi¹  Toru Mazaki²  Hiroyoshi Yokoi²  Iichiro Shimomura³  Yasuhiko Nakagawa³  Tohru Funahashi⁴  Ken Kishida⁵  Hironori Kobayashi⁶ 

[1] Department of Cardiology, Kenporen Osaka Central Hospital, Osaka, Osaka, Japan;Department of Cardiology, Kokura Memorial Hospital, Kokura, Fukuoka, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Metabolism and Atherosclerlosis, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Kishida Clinic, Toyonaka, Osaka, Japan;Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima, Tokushima, Japan;

关键词: Adiponectin;    C1q;    C1q-binding adiponectin;    Acute coronary syndrome;   

DOI  :  10.1186/1475-2840-13-9

 received in 2013-12-21, accepted in 2014-01-02,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and serum C1q binding adiponectin (C1q-APN) can be measured. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls.MethodsThe study subjects were 138 Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays. Patients were divided into three groups according to the clinical condition: ACS (n = 78), SAP (n = 41) or normal coronary (NC, n = 19) groups.ResultsSerum C1q levels were significantly higher in the ACS group (54.9±1.2 μg/mL) than in the NC group (48.0±2.5 μg/mL). Although serum Total-APN levels were significantly lower in the SAP and ACS groups, compared with the NC group (7.0±0.5, 7.2±0.3, 10.6±2.0 μg/mL, respectively), serum C1q-APN levels were significantly higher in the ACS group than in the NC and SAP groups (112.1±4.1, 66.3±4.4, 65.7±2.9 units/mL, respectively).ConclusionsPatients with ACS had higher serum C1q-APN levels.Trial RegistrationUMIN000002997

【 授权许可】

CC BY   
© Kishida et al.; licensee BioMed Central Ltd. 2014