Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Diabetology & Metabolic Syndrome

Iichiro Shimomura²  Tohru Funahashi⁴  Koji Yanagi¹  Hironori Kobayashi⁵  Yasuhiko Nakagawa²  Ken Kishida³ 

[1] Department of Cardiology, Kenporen Osaka Central Hospital, Osaka, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Kishida Clinic, Toyonaka, Osaka, Japan;Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

关键词: Angiographic coronary vessel;    Coronary artery disease;    C1q-binding adiponectin;    C1q;    Adiponectin;   

Others  :  803537
DOI  :  10.1186/1758-5996-6-64

 received in 2014-03-27, accepted in 2014-05-20,  发布年份 2014

【 摘 要 】

Background

Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are associated with CAD in type 2 diabetic subjects. The present study investigated the relationship between circulating C1q-APN levels and the number of angiographic coronary artery vessel in male subjects.

Methods

The study subjects were 53 male Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), high-molecular weight adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays.

Results

Serum C1q-APN/Total-APN ratio significantly increased in subjects with single and multi-vessel coronary diseases (p = 0.029 for trend, the Kruskal-Wallis test). However, serum Total-APN, HMW-APN, C1q-APN and C1q levels did not correlate with number of diseased coronary vessels.

Conclusion

Serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary disease.

Trial registration

UMIN000002997

【 授权许可】

   
2014 Kishida et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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