Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report

Diabetology & Metabolic Syndrome

Iichiro Shimomura¹  Tohru Funahashi³  Tohru Nakagawa⁴  Hironori Kobayashi⁵  Ken Kishida²  Hideaki Nakatsuji¹ 

[1] Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;Kishida Clinic, Osaka 560-0021, Japan;Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;Hitachi, Ltd. Hitachi Health Care Center, Hitachi, Ibaraki, 317-0076, Japan;Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima 771-0195, Japan

关键词: Aging;    C1q-binding adiponectin;    C1q;    Adiponectin;   

Others  :  814005
DOI  :  10.1186/1758-5996-5-17

 received in 2013-02-03, accepted in 2013-03-22,  发布年份 2013

【 摘 要 】

Background

Atherosclerosis is an age-related disease. Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated circulating C1q and C1q-APN levels in Japanese men including elderly men.

Findings

The study subjects were 509 Japanese men including elderly men. Serum levels of total adiponectin (Total-APN), high-molecular weight-adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assay. Total-APN, HMW-APN and C1q-APN, but not C1q, correlated significantly and positively with aging (r=0.26, r=0.24, r=0.17, p<0.01, respectively). The HMW-APN/Total-APN ratio correlated significantly and positively with aging (r=0.14, p<0.01). The C1q-APN/Total-APN ratio and C1q-APN/HMW-APN ratio correlated significantly and negatively with aging (r=−0.17, p<0.01, r=−0.12, p=0.01). C1q-APN/C1q correlated significantly and positively with aging (r=0.09, p=0.03). Multiple regression analysis identified age and body mass index as significant determinants of C1q-APN.

Conclusions

The present study demonstrates that serum HMW-APN, C1q-APN, and Total-APN, but not C1q, correlated positively with aging. These preliminary results could form the basis for future research.

Trial registration

Clinical Trial Registration Number: UMIN000004318

【 授权许可】

   
2013 Nakatsuji et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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