Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet

Lipids in Health and Disease

Research

Csaba Kónya¹  Judit Bárkányi¹  Csilla Szűcs¹  Gergő Szűcs²  Renáta Gáspár²  Tamás Csont³  Péter Bencsik³  Csaba Csonka³  Márta Sárközy³  Imre Földesi⁴  Péter Ferdinandy⁵ 

[1] Béres Pharmaceuticals Ltd, Budapest, Hungary;Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary;Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary;Pharmahungary Group, Szeged, Hungary;Department of Laboratory Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary;Pharmahungary Group, Szeged, Hungary;Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary;

关键词: Multivitamin;    Multimineral;    Prevention;    Hypercholesterolemia;    Cardiovascular risk;    Inflammation;    Oxidative stress;   

DOI  :  10.1186/1476-511X-12-138

 received in 2013-07-30, accepted in 2013-09-13,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundAlthough complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia which is a major risk factor for cardiovascular diseases. Therefore, here we investigated if a preparation developed for human use containing different vitamins, minerals and trace elements enriched with phytosterol (VMTP) affects the severity of experimental hyperlipidemia as well as myocardial ischemia/reperfusion injury.MethodsMale Wistar rats were fed a normal or cholesterol-enriched (2% cholesterol + 0.25% cholate) diet for 12 weeks to induce hyperlipidemia. From week 8, rats in both groups were fed with a VMTP preparation or placebo for 4 weeks. Serum triglyceride and cholesterol levels were measured at week 0, 8 and 12. At week 12, hearts were isolated, perfused according to Langendorff and subjected to a 30-min coronary occlusion followed by 120 min reperfusion to measure infarct size.ResultsAt week 8, cholesterol-fed rats showed significantly higher serum cholesterol level as compared to normal animals, however, serum triglyceride level did not change. VMTP treatment significantly decreased serum cholesterol level in the hyperlipidemic group by week 12 without affecting triglyceride levels. However, VMTP did not show beneficial effect on infarct size. The inflammatory marker hs-CRP and the antioxidant uric acid were also not significantly different.ConclusionsThis is the first demonstration that treatment of hyperlipidemic subjects with a VMTP preparation reduces serum cholesterol, the major risk factor for cardiovascular disease; however, it does not provide cardioprotection.

【 授权许可】

Unknown   
© Csont et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.