Predictive value of the time interval between embryo loading and transfer for IVF/ICSI success: a prospective cohort study

Reproductive Biology and Endocrinology

Research

Katharina Walch¹  Sema Dag¹  Johannes Ott¹  Kazem Nouri¹  Clemens B. Tempfer²  Regina Promberger³ 

[1] Department of Obstetrics and Gynecology, Clinical Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria;Department of Obstetrics and Gynecology, Ruhr University Bochum, Bochum, Germany;Marienhospital Herne, Hoelkeskampring 40, 44625, Herne, Germany;Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria;

关键词: Embryo transfer;    Catheter;    Embryo loading time;    Pregnancy rate;    Live birth rate;   

DOI  :  10.1186/s12958-015-0048-6

 received in 2015-03-31, accepted in 2015-05-21,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe influence of embryo loading time (ELT) and the time interval between embryo loading and embryo transfer (TIEL-ET) on the success of IVF/ICSI is unknown.MethodsIn a prospective cohort study, we aimed to ascertain the influence of ELT and TIEL-ET on ongoing pregnancy rate (OPR) and life birth rate (LBR). Data from 603 consecutive embryo transfers between January 2008 and December 2013 were collected. A complete data set including the outcomes of interest OPR and LBR was available for 410 women. The primary outcome was IVF/ICSI success, defined as OPR and LBR.ResultsWe used univariate and multivariate logistic regression for analysis. In a multivariate analysis, age (odds ratio [OR] 0.94; 95 % confidence interval [CI] 0.89–0.99), catheter type (OR 0.45; 95 % CI 0.24–0.84), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independently associated with OPR. Regarding LBR, age (OR 0.93; 95 % CI 0.88–0.98), catheter type (OR 0.41; 95 % CI 0.22–0.79), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independent predictors.ConclusionWe conclude that speed of embryo transfer is not critical for the success of IVF/ICSI. However, care should be taken to choose catheter types proven to be associated with a high success rate.

【 授权许可】

Unknown   
© Nouri et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.