Predictive value of the time interval between embryo loading and transfer for IVF/ICSI success: a prospective cohort study

Reproductive Biology and Endocrinology

Johannes Ott²  Sema Dag²  Regina Promberger¹  Katharina Walch²  Clemens B. Tempfer³  Kazem Nouri² 

[1] Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria;Department of Obstetrics and Gynecology, Clinical Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria;Marienhospital Herne, Hoelkeskampring 40, Herne, 44625, Germany

关键词: Live birth rate;    Pregnancy rate;    Embryo loading time;    Catheter;    Embryo transfer;   

Others  :  1216408
DOI  :  10.1186/s12958-015-0048-6

 received in 2015-03-31, accepted in 2015-05-21,  发布年份 2015

【 摘 要 】

Background

The influence of embryo loading time (ELT) and the time interval between embryo loading and embryo transfer (TIEL-ET) on the success of IVF/ICSI is unknown.

Methods

In a prospective cohort study, we aimed to ascertain the influence of ELT and TIEL-ET on ongoing pregnancy rate (OPR) and life birth rate (LBR). Data from 603 consecutive embryo transfers between January 2008 and December 2013 were collected. A complete data set including the outcomes of interest OPR and LBR was available for 410 women. The primary outcome was IVF/ICSI success, defined as OPR and LBR.

Results

We used univariate and multivariate logistic regression for analysis. In a multivariate analysis, age (odds ratio [OR] 0.94; 95 % confidence interval [CI] 0.89–0.99), catheter type (OR 0.45; 95 % CI 0.24–0.84), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independently associated with OPR. Regarding LBR, age (OR 0.93; 95 % CI 0.88–0.98), catheter type (OR 0.41; 95 % CI 0.22–0.79), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independent predictors.

Conclusion

We conclude that speed of embryo transfer is not critical for the success of IVF/ICSI. However, care should be taken to choose catheter types proven to be associated with a high success rate.

【 授权许可】

   
2015 Nouri et al.; licensee BioMed Central.

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