Arterial stiffness, fatty liver and the presence of coronary artery calcium in a large population cohort

Cardiovascular Diabetology

Original Investigation

Jeong Bae Park¹  Jin-Ho Shin²  Young-Hyo Lim²  Ki-Chul Sung³  Byung-Jin Kim³  Seok-Min Kang⁴  Sungha Park⁴ 

[1] Division of Cardiology, Department of Internal Medicine, Cheil General Hospital, College of Medicine, Kwandong University, Seoul, Republic of Korea;Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea;Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108, Pyung Dong, 110-746, Jongro-Ku, Seoul, Republic of Korea;Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, College of Medicine, Yonsei University, Seoul, Republic of Korea;

关键词: baPWV;    Arterial stiffness;    Coronary artery calcium (CAC) score;    Atherosclerosis;    Fatty liver;   

DOI  :  10.1186/1475-2840-12-162

 received in 2013-09-10, accepted in 2013-11-02,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundWe tested whether fatty liver, brachial-ankle pulse wave velocity (baPWV) and conventional cardiovascular risk factors were associated with a coronary artery calcium (CAC) score > 0 (as a marker of the presence of early atherosclerosis) in a cohort of healthy Korean adults.MethodThe study population consisted of individuals who underwent a comprehensive health examination in 2010 at Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University in South Korea. The 6009 subjects of total 7371 participants who had an assigned CAC score following coronary computed tomography (CT) scanning and baPWV were analyzed.ResultsAmong the study subjects, 39.2% of the population had evidence of fatty liver by ultrasound and 4.6% of the population had evidence of CAC score > 0. Among individuals with a CAC score = 0, 38% of the individuals had fatty liver compared with 58% of the individuals with a CAC score > 0. The individuals with a CAC score > 0 also had higher blood pressure and had more metabolic abnormalities. The prevalence of CAC score > 0 was increased according to baPWV quartiles and was higher in the fatty liver group in comparison with those without fatty liver. The odds ratio for CAC score > 0, after adjusting for clinical risk factors, showed a significant elevation with increasing quartiles of baPWV and the presence of fatty liver.ConclusionWe showed that both fatty liver and baPWV are independently associated with the presence of CAC, a marker of preclinical atherosclerosis. These associations are independent of conventional risk factors and medical history.

【 授权许可】

CC BY   
© Sung et al.; licensee BioMed Central Ltd. 2013